NanoSpark™ GROW-NK
Soluble Activator

The NanoSparkTM GROW-NK Soluble Activator uses anti-NKp46 & anti-CD2 mAbs on the NanoSparkTM platform to activate and expand NK cells in an easy-to-use, feeder-free manner.
  • High performance
  • Feeder-free
  • Soluble, all protein-based
  • No magnetic components

Part Number: GROW-NK

 

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$325.00

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If you are purchasing outside of the United States, Canada, China, Germany, Japan, Sweden, Switzerland, Taiwan, or United Kingdom – Please contact info@nanoteintech.com to complete your purchase.

Description

The NanoSparkTM GROW-NK Soluble Activator is a culture-ready, feeder-free reagent for in vitro activation and expansion of human NK cells. The nanoscale of the NanoSparkTM GROW-NK protein complex allows for sterile filtration and removal of excess reagent via either media exchange or simple centrifugal cell washing.

Documents

View NK Data Sheet 2023 (IL-2 & IL-15)

View Nanotein STEM T SDS

FAQ's

Coming soon.

Quality & Safety

The underlying NanoSparkTM platform has undergone biocompatibility testing when formulated with antibodies specific to our T cell activator, STEM-T, which we consider a significant derisking step for the platform as a whole. The details are as follows:

The composition of the NanoSparkTM reagent is protein-based, and consequently naturally biodegradable, which provides a significant safety advantage over magnetic bead-based and synthetic products. A reputable medical device CRO was commissioned to complete the in vitro & in vivo ISO 10993 biocompatibility testing.  The tests were run at >20X the predicted possible carry-over amount, which resulted in no toxicity or adverse effects:

ISO 10993 

Biocompatibility Testing

Test Type of Test Result Product Tested
ISO 10993-5 Cytotoxicity In vitro No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-10 Sensitization In vivo: Guinea Pig No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-10 Irritation/Intracutaneous Reactivity In vivo: Rabbits No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-11 Acute Systemic Toxicity In vivo: Mice No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-11 Pyrogenicity In vivo: Rabbits No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-4 Hemocompatibility In vitro No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-3 Genotoxicity Ames In vitro No Toxicity/Adverse Effect NanoSpark STEM-T
ISO 10993-3 Genotoxicity Mouse Lymphoma Forward Mutation In vitro No Toxicity/Adverse Effect NanoSpark STEM-T

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