NanoSpark STEM-T Soluble T Cell Activator

The NanoSpark STEM-T Soluble T Cell Activator reagent kit is an easy-to-use T cell activator for T cell expansion, including CAR-T cells.

  • Soluble format
  • All protein-based
  • No magnetic components
  • High total & stemlike CD8+ T cell production
  • Anti-CD3/CD28 based

Add the NanoSpark STEM-T Soluble T Cell Activator to cart now!

If you are purchasing outside of the United States, Canada, China, Germany, Japan, Sweden, Switzerland, Taiwan, or United Kingdom – Please contact info@nanoteintech.com to complete your purchase.

Description

Product Highlights

The NanoSpark STEM-T Soluble T Cell Activator is a culture-ready reagent for in vitro activation and expansion of human T cells. The nanoscale of the NanoSpark STEM-T protein complex allows for sterile filtration and removal of excess reagent via either media exchange or simple centrifugal cell washing.

  • Convenient

    Soluble, magnetic bead-free, protein-based, and ready-to-use.

  • High Performance

    Excellent total T cell expansion with industry-leading clinically desirable CD8+ stem cell memory T cell expansion.

  • Reliable

    Employs anti-CD3/CD28 antibodies and maintains high cell viability.

Additional information

Weight7 lbs
Dimensions9 × 9 × 9 in

Documents

Data Sheets

View STEM T Cell Data Sheet 2022 (IL-2)

View STEM T Cell Data Sheet 2022 (IL-7 & IL-15)

Certificate of Analysis (CoA) Example

View Nanotein Example STEM T CoA

Safety Data Sheet (SDS)

View Nanotein STEM T SDS

FAQ's

Quality & Safety

Nanotein assessed the NanoSpark activator with adherence to rigorous ISO 10993 standards in preparation for GMP manufacturing. The composition of the NanoSpark reagent is protein-based, and consequently naturally biodegradable, which provides a significant safety advantage over magnetic bead-based and synthetic products. A reputable medical device CRO was commissioned to complete the in vitro & in vivo ISO 10993 biocompatibility testing.  The tests were run at >20X the predicted possible carry-over amount, which resulted in no toxicity or adverse effects:

ISO 10993 

Biocompatibility Testing

TestType of TestResultProduct Tested
ISO 10993-5CytotoxicityIn vitroNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-10SensitizationIn vivo: Guinea PigNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-10Irritation/Intracutaneous ReactivityIn vivo: RabbitsNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-11Acute Systemic ToxicityIn vivo: MiceNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-11PyrogenicityIn vivo: RabbitsNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-4HemocompatibilityIn vitroNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-3Genotoxicity AmesIn vitroNo Toxicity/Adverse EffectNanoSpark STEM-T
ISO 10993-3Genotoxicity Mouse Lymphoma Forward MutationIn vitroNo Toxicity/Adverse EffectNanoSpark STEM-T

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