Nanotein & Akron Bio Partner for cGMP production of NanoSpark® STEM-T Soluble T Cell Activator. Read More

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Our Science

Simply put, we outperform the competition.

T CELLS
With our first product, STEM-T, we are able to outperform current commercial competitors by producing up to:
CD8+ Tscm cells
2 x
CD4+ Tscm cells
2 x
Total T cells
2 x
NK CELLS
Our GROW-NK product makes NK feeder cells obsolete
View Product Pipeline
NanoSpark® Improves Cell Therapy Biomanufacturing

1

Extraction & Isolation of Immune Cells From the Patient

Immune cells are harvested from the patient’s blood for further genetic modification.

2

Cell Activation

Our best-in-class activation reagents prepare the isolated immune cells for genetic modification.

3

Viral Transduction (or electroporation)

The genetic material and machinery to accomplish gene editing enters the cells.

4

Genetically Engineer Cells to Express a Chimeric Antigen Receptor (CAR)

Cells are engineered to express CARs, enabling them to recognize and destroy cancer cells.

5

Cell Expansion

NanoSpark® STEM-T or GROW-NK reagents facilitate the rapid and efficient expansion of the engineered immune cells.

6

Reinfusion of Engineered Cells into Patient

The engineered cells are reinfused into the patient, where they target and attack cancer cells.
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Destruction of
cancer cells

NanoSpark® Improves Cell Therapy Biomanufacturing
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1

Extraction & Isolation of Immune Cells From the Patient

Immune cells are harvested from the patient’s blood for further genetic modification.

2

Cell Activation

Our best-in-class activation reagents prepare the isolated immune cells for genetic modification.

3

Viral Transduction (or electroporation)

The genetic material and machinery to accomplish gene editing enters the cells.

4

Genetically Engineer Cells to Express a Chimeric Antigen Receptor (CAR)

Cells are engineered to express CARs, enabling them to recognize and destroy cancer cells.

5

Cell Expansion

NanoSpark® STEM-T or GROW-NK reagents facilitate the rapid and efficient expansion of the engineered immune cells.

6

Reinfusion of Engineered Cells into Patient

The engineered cells are reinfused into the patient, where they target and attack cancer cells.
Mobile-Destruction-of
cancer-cells.png

Destruction of
cancer cells

NanoSpark® Improves Cell Therapy Biomanufacturing

1

Extraction & Isolation of T cells

2

Viral Transduction

3

Genetically engineer CAR-T cells to express a chimeric antigen receptor (CAR)

4

T cell activation & expansion: Nanotein’s superior reagents are combatting a key challenge of CAR-T therapeutics to manufacture long-lived, self-renewing CAR-T cells with increased efficacy that avoid patient relapse

5

Reinfusion of CAR-T cells into patient

6

Destruction of cancer cells

Our “Plug & Play” Platform Technology

Our technology is based on a self-assembling protein nanoparticle core, that displays antibodies and cytokines, in meaningfully unique geometric orientations. This drives best-in-class expansion reactions.
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Advanced Immune Cell Activations

Best-in-class results in most protocols vs. competing soluble activation reagents

Superior T Cell Expansions

  • Greater stemness and increased T cell numbers
  • No beads = no removal
  • Soluble and all protein-based
  • No synthetic component contamination
LEARN MORE ABOUT NANOSPARK® STEM-T

Efficient T-Cell Activation

  • Control over CD4+:CD8+ T cell production
  • Activates resting human CD3+ T cells
  • Soluble and magnetic bead-free
  • Protein-based and ready to use
LEARN MORE ABOUT NANOSPARK® EVEN-T
User selects CD8+:CD4+ ratios using a simple tunable protocol
NanoSpark® GROW-NK vs Feeder Expansions

Competitive NK Expansions & Efficient Killing

  • Long-term, feeder-free expansion
  • Enhanced NK cell growth rate
  • Soluble and all protein-based
  • No magnetic components
LEARN MORE ABOUT NANOSPARK® GROW-NK

FAQs

Our CAR-T reagents help customers to make better, more effective cell therapies, faster.
Yes, under optimal conditions.
Yes, we are working towards a GMP version. Stay up-to-date with our progress by exploring our pipeline.

This is unavailable at this time, but may be possible through collaboration with us. Visit our contact page to get in touch.

Purchase Our NanoSparkTM Products

Explore our range of cutting-edge NanoSparkTM products designed for superior cell activation and expansion.
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